Package: PopComm
Title: Population-Level Cell-Cell Communication Analysis Tools
Version: 1.0.1
Authors@R: 
    c(person(given = "Zheng", family = "Gong", email = "gongzheng131@hotmail.com", role = c("aut", "cre"), 
    comment = c(ORCID = "0000-0001-7285-2630")),
    person(given = "Mengwei", family = "Li", email = "limengwei833@gmail.com", role = c("aut", "ctb"),
    comment = c(ORCID = "0000-0001-6163-2827")))
Description: Facilitates population-level analysis of ligand-receptor
        (LR) interactions using large-scale single-cell transcriptomic
        data. Identifies significant LR pairs and quantifies their
        interactions through correlation-based filtering and projection
        score computations. Designed for large-sample single-cell
        studies, the package employs statistical modeling, including
        linear regression, to investigate LR relationships between cell
        types. It provides a systematic framework for understanding
        cell-cell communication, uncovering regulatory interactions and
        signaling mechanisms. Offers tools for LR pair-level,
        sample-level, and differential interaction analyses, with
        comprehensive visualization support to aid biological
        interpretation. The methodology is described in a manuscript
        currently under review and will be referenced here once
        published or publicly available.
URL: https://github.com/JusticeGO/PopComm
BugReports: https://github.com/JusticeGO/PopComm/issues
biocViews:
Depends: R (>= 4.1.0)
Imports: Seurat (>= 4.1.0), broom (>= 1.0.0), dplyr (>= 1.0.0), purrr
        (>= 0.3.0), rlang, stringr (>= 1.4.0), tibble (>= 3.0.0), tidyr
        (>= 1.0.0), tidyselect (>= 1.1.0), Matrix (>= 1.2-0), ggplot2
        (>= 3.3.0), ggpubr (>= 0.6.0), pheatmap (>= 1.0.12),
        RColorBrewer, reshape2 (>= 1.4.1), scales (>= 1.1.1), igraph
        (>= 2.0.0), parallel, pbmcapply (>= 1.5.0), grDevices, cowplot
        (>= 1.1.1)
License: MIT + file LICENSE
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.2.3
LazyData: true
Config/pak/sysreqs: cmake libglpk-dev make libicu-dev libpng-dev
        libuv1-dev libxml2-dev libssl-dev python3 zlib1g-dev
Repository: https://justicego.r-universe.dev
Date/Publication: 2026-02-04 09:00:31 UTC
RemoteUrl: https://github.com/justicego/popcomm
RemoteRef: HEAD
RemoteSha: 6e4d7ba83582b8d57d70e4ae2b5ea1a567768e38
NeedsCompilation: no
Packaged: 2026-10-23 07:29:57 UTC; root
Author: Zheng Gong [aut, cre] (ORCID: <https://orcid.org/0000-0001-7285-2630>),
  Mengwei Li [aut, ctb] (ORCID: <https://orcid.org/0000-0001-6163-2827>)
Maintainer: Zheng Gong <gongzheng131@hotmail.com>